Emergency services were called to Leason Road, Meir, shortly before 3pm today.
The pedestrian, a man, has suffered serious injuries.
The air ambulance has now left the scene – and the man has been taken to Royal Stoke University Hospital by land ambulance.
A West Midlands Ambulance Service spokesman said: “We were called at 2.41pm to reports of a collision between a car and a pedestrian on Leason Road.
“We sent one ambulance and a paramedic officer and the Midlands Air Ambulance from Cosford to the scene.
“On arrival we discovered one patient, a male, who was the pedestrian. He has been treated for serious injuries, not believed to be life threatening and he was taken to Royal Stoke University Hospital by land ambulance.
“The doctor from the air ambulance travelled in the back of the ambulance to help continue treatment on route.”
Traffic monitoring company Inrix reports that Leason Road is partially blocked.
A spokesman said: “Leason Road partially blocked, slow traffic due to accident at Brookhouse Road.”