The accident has taken place on the southbound carriageway between junction 19 (A556/Knutsford) and junction 18 (A54/Middlewich/Holmes Chapel).
A lorry is involved in the accident.
Lane one of four is currently closed and the accident was first reported by traffic data company Inrix shortly after 9.30am today (Monday November 30).
We have no further information on any other vehicles involved at this stage.
An Inrix spokesman said: “One lane closed due to accident, a lorry involved on M6 Southbound between J19 A556 (Knutsford) and J18 A54 Middlewich Road (Middlewich / Holmes Chapel). Traffic is coping well.
“Lane one (of four) is closed.”
We will bring you more information on this closure as we get it.