More than 300 coronavirus positive patients are currently in Royal Stoke and County Hospitals.
Tracy Bullock, chief executive at the University Hospitals of North Midlands which runs both hospitals, took to social media to reveal a surge in cases.
It came as Public Health England and the Department of Health and Social Care revealed another 208 people had tested positive for the virus in the last 24 hours.
The health boss said: “Over 300 positive patients at UHNM more than double the first surge.”
Elsewhere in Stoke-on-Trent, the first fast-turnaround lateral flow tests were conducted at Dimensions Leisure Centre in Burslem.
This saw over 100 asymptomatic residents tested to see if they had the virus.
Dr Paul Edmondson-Jones, director of social care, health integration and well-being at Stoke-on-Trent City Council said: “Another difficult day as 208 new cases notified means our seven day rate has risen past 500 for the first time to 503.4 per 100,000.
“We must do more this weekend.
“Today was ground breaking in the City – we launched our first lateral flow test session this morning at Dimensions. We saw 160 asymptomatic residents and 7 of them tested positive.
“This enables us to give advice & intervene days earlier than through PCR test.”