The lorry came to rest in a field after the HGV collided with a silver Vokswagen Golf causing it to leave the carriageway.
Two lanes remain closed while recovery work takes place.
There were no injuries as a result of the collision.
A Cheshire Police spokesman said: “At around 2am on Friday 15 January police were called to reports of a collision on the M6 southbound between junctions 17 and 16.
“Officers attended the scene and found a HGV had collided with a silver Volkswagen Golf, causing the HGV to leave the carriageway and stop in a nearby field.
“There were no injuries as a result of the incident.
“Two lanes remain closed at the current time while recovery work takes place.”